Author

Jacob A. Stern

Brigham Young UniversityORCID 0000-0003-0138-0829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Approach:Bayesian inference· 1 Approach:deep learning· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Dennis Della CorteiD· 2 shared Anandsukeerthi SandholuiD· 1 shared Bradley Charles BundyiD· 1 shared David WingateiD· 1 shared Joshua L. PriceiD· 1 shared Kimberlee L. Stern· 1 shared Nicholas A. Dalley· 1 shared Siba AlharbiiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSynthetic Biology

Dennis Della CorteORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintApr 23, 2025

Conformation-specific Design: a New Benchmark and Algorithm with Application to Engineer a Constitutively Active MAP Kinase

Jacob A. Stern, Siba Alharbi, Anandsukeerthi Sandholu…·Dennis Della Corte

The paper introduces a benchmark and algorithm for designing proteins with conformational specificity, demonstrating success in redesigning MAP kinase ERK2 to maintain activity without phosphorylation.

2 citations

humanprotein sequence

𝕏 PostBluesky

BioinformaticsScientific ReportsPeer-reviewedSep 19, 2023

A probabilistic view of protein stability, conformational specificity, and design

Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern…·Dennis Della Corte

The paper defines protein stability and conformational specificity probabilistically and introduces BayesDesign, a sequence decoding algorithm that maximizes p(structure|seq) for protein design.

10 citations

protein sequenceBayesian inference

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