Author

Spencer Gardiner

Brigham Young University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

Dennis Della CorteiD· 3 shared Bradley Charles BundyiD· 2 shared A.M. EdwardsiD· 1 shared Aiping DongiD· 1 shared Akhila MettuiD· 1 shared Albina Bolotokova· 1 shared Aleksandra IvanováiD· 1 shared Alexander FürlliD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

Dennis Della CorteORCID

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Author profile →

3 papers

Recent·Most cited

Advancing Luciferase Activity and Stability beyond Directed Evolution and Rational Design through Expert Guided Deep Learning

Spencer Gardiner, Joseph Talley, Tyler Green, Christopher Haynie, Corbyn Kubalek, Matthew Argyle, William P. Heaps, Joshua L. Ebbert, Deon Allen, Dallin Chipman, Bradley Charles Bundy, Dennis Della Corte

This paper develops enhanced NanoLuc luciferase variants using a hybrid approach of deep learning and structure-guided design, improving thermostability and activity at elevated temperatures.

ACS Catalysis · Jan 27, 2026Peer-reviewedBiochemistry

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

Fengling Li, Suzanne Z. Ackloo, C. H. Arrowsmith, Fuqiang Ban, Christopher Barden, Hartmut Beck, Jan Beránek, Francois Berenger, Albina Bolotokova, Guillaume Bret, Marko Breznik, Emanuele Carosati, Irene Chau, Yu Chen, Artem R Cherkasov, , Matthieu Schapira

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

Journal of Chemical Information and Modeling · Nov 5, 2024Peer-reviewedBiochemistry

A probabilistic view of protein stability, conformational specificity, and design

Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley Charles Bundy, Joshua L. Price, David Wingate, Dennis Della Corte

The paper defines protein stability and conformational specificity probabilistically and introduces BayesDesign, a sequence decoding algorithm that maximizes p(structure|seq) for protein design.

Scientific Reports · Sep 19, 2023Peer-reviewedBioinformatics