Correcting subtle stratification in summary association statistics
Gaurav Bhatia, Nicholas A. Furlotte, Po-Ru Loh, Xuanyao Liu, Hilary K. Finucane, Alexander Gusev, Alkes L. Price
This paper introduces PC loading regression to correct population stratification in GWAS summary statistics, showing it reduces LDSC intercept inflation in traits like height and eye color.
bioRxiv · Sep 19, 2016 · PreprintGenetics