Author

Po-Ru Loh

Primary ORCID profile (0000-0001-5542-9064 · 14 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Po-Ru LohiD14 papers · Brigham and Women's Hospital

Biology Disciplines

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Genetics· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:benchmarking· 2 Research Focus:variant effect prediction· 2 Research Focus:fine-mapping· 1 Approach:mixed model· 1

Frequent Co-Authors

Alkes L. Price· 4 shared Alexander Gusev· 3 shared Gaurav Bhatia· 2 shared Hilary Finucane· 2 shared Nick Patterson· 2 shared Noah A. Zaitlen· 2 shared Aarno Palotie· 1 shared Abhishek K. Sarkar· 1 shared

Activity by Year

2016-2016 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersGenetics

Alkes L. Price

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Author profile →

4 papers

Recent·Most cited

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman, Hilary Finucane, Patrick Sulem, Katherine S. Ruth, Sean Whalen, Abhishek K. Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M. Barbieri, Thibaud Boutin, Archie Campbell, , John R.B Perry

This study identifies 389 genetic signals for age at menarche and finds BMI-independent causal links between puberty timing and cancer risks.

bioRxiv · Sep 23, 2016 · PreprintGenomics

Correcting subtle stratification in summary association statistics

Gaurav Bhatia, Nicholas A. Furlotte, Po-Ru Loh, Xuanyao Liu, Hilary K. Finucane, Alexander Gusev, Alkes L. Price

This paper introduces PC loading regression to correct population stratification in GWAS summary statistics, showing it reduces LDSC intercept inflation in traits like height and eye color.

bioRxiv · Sep 19, 2016 · PreprintGenetics

Subtle stratification confounds estimates of heritability from rare variants

Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Hilary Finucane, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Sang Hong Lee, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, , Alkes L. Price

This study shows that subtle population stratification can confound heritability estimates from rare variants, even after standard corrections, suggesting the need for better stratification control in genetic studies.

bioRxiv · Apr 13, 2016 · PreprintGenetics

Mixed Model Association with Family-Biased Case-Control Ascertainment

Tristan Hayeck, Noah A. Zaitlen, Po-Ru Loh, Samuela Pollack, Alexander Gusev, Nick Patterson, Alkes L. Price

This paper introduces LT-Fam, a family-based association statistic that is robust to family-biased case-control ascertainment, showing improved calibration and power compared to existing methods.

bioRxiv · Apr 5, 2016 · PreprintGenetics