Alexander Gusev

Correcting subtle stratification in summary association statistics

This paper introduces PC loading regression to correct population stratification in GWAS summary statistics, showing it reduces LDSC intercept inflation in traits like height and eye color.

Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

This study integrates gene expression with GWAS summary statistics to identify 1,196 susceptibility genes for 30 complex traits, including new risk loci and causal relationships between traits.

Subtle stratification confounds estimates of heritability from rare variants

This study shows that subtle population stratification can confound heritability estimates from rare variants, even after standard corrections, suggesting the need for better stratification control in genetic studies.

Mixed Model Association with Family-Biased Case-Control Ascertainment

This paper introduces LT-Fam, a family-based association statistic that is robust to family-biased case-control ascertainment, showing improved calibration and power compared to existing methods.