Hypoosmolar dose-dependent swelling occurs in both pyramidal neurons and astrocytes in acute hippocampal slices
Thomas R. Murphy, David Davila, Nicholas Cuvelier, Leslie R. Young, Kelli Lauderdale, Devin K. Binder, Todd A. Fiacco
This study shows that both pyramidal neurons and astrocytes swell in hypoosmolar conditions, challenging the notion of neuronal osmoresistance and revealing an AQP4-independent mechanism for osmotic swelling.
Frontiers in Cellular Neuroscience · Sep 20, 2017Peer-reviewedNeuroscience