DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats
Nicholas J. Pederson, Katharine L. Diehl
This study identifies that SIRT6 mono-ADP-ribosylates proteins with polyhistidine repeats when bound to dsDNA ends, revealing it as a histidine mARyltransferase.
Journal of Biological Chemistry · Apr 23, 2025Peer-reviewedBiochemistry