Author

Katharine L. Diehl

University of UtahORCID 0000-0002-9872-7501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Faheem FaheemiD· 1 shared Garrison A. NickeliD· 1 shared Jack Bulf· 1 shared Nicholas J Pederson· 1 shared Nicholas J. Pederson· 1 shared Zhenyu YangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

Faheem FaheemORCID

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2 papers

Recent·Most cited

Sirtuin 6 is a histone delactylase

Garrison A. Nickel, Nicholas J Pederson, Faheem Faheem, Zhenyu Yang, Jack Bulf, Katharine L. Diehl

This study identifies Sirtuin 6 as a histone delactylase and shows its delactylase activity at H3K9 and H3K18, with additive effects to Class I HDACs in regulating histone Kla.

Journal of Biological Chemistry · Oct 7, 2025Peer-reviewedBiochemistry

DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats

Nicholas J. Pederson, Katharine L. Diehl

This study identifies that SIRT6 mono-ADP-ribosylates proteins with polyhistidine repeats when bound to dsDNA ends, revealing it as a histidine mARyltransferase.

Journal of Biological Chemistry · Apr 23, 2025Peer-reviewedBiochemistry