Inference of CRISPR Edits from Sanger Trace Data
Tim Hsiau, David Conant, Nicholas Rossi, Travis J. Maures, Kelsey Waite, Joyce L. Yang, Sahil Joshi, Reed Kelso, Kevin Holden, Brittany L. Enzmann, Rich Stoner
ICE regresses simulated edit traces onto Sanger reads to quantify indels, multi-guide and knock-in edits without tuning, correlating with amplicon sequencing (r2 = 0.93) and TIDE (r2 = 0.99).
bioRxiv · Aug 10, 2019 · PreprintBioinformatics✦ In-depth digest