Author

Joyce L. Yang

Gladstone InstitutesORCID 0000-0001-7341-7403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Jonathan Xianglong MengiD· 2 shared Alexander R. PicoiD· 1 shared Brian J. BacskaiiD· 1 shared Brittany L. Enzmann· 1 shared Christine A. Dauphinais· 1 shared Daniel P. KellyiD· 1 shared David Conant· 1 shared Isha H. JainiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersNeuroscience

Jonathan Xianglong MengORCID

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4 papers

Recent·Most cited

Requirement for oxidation of neuronal ketone bodies in aging andneurodegeneration

Joyce L. Yang, Mitsunori Nomura, Jonathan Xianglong Meng, Thelma Y. Garcia, Timothy R. Matsuura, Daniel P. Kelly, Ken-Ichi Nakamura, John C. Newman

This study shows ketone body oxidation is essential for neuronal function and survival, particularly in neurodegenerative diseases like Alzheimer's.

bioRxiv · Mar 27, 2026 · PreprintNeuroscience

Genetic regulators of neuronal survival across metabolic environments

Neal K. Bennett, Yanilka Soto-Muniz, Jonathan Xianglong Meng, Megan Lee, Joyce L. Yang, Will Flanigan, Alexander R. Pico, Isha H. Jain, Ken Nakamura

The paper identifies genetic regulators of neuronal survival across different metabolic environments using CRISPRi screens in human neurons.

bioRxiv · Dec 19, 2025 · PreprintSystems Biology

Shallow-angle intracranial cannula for repeated infusion and in vivo imaging with multiphoton microscopy

Steven S. Hou, Joyce L. Yang, Yeseo Kwon, Qi Pian, Yijing Tang, Christine A. Dauphinais, María Calvo-Rodríguez, Mirna El Khatib, Sergei A. Vinogradov, Sava Sakadžić, Brian J. Bacskai

The paper introduces a shallow-angle cannula for repeated drug delivery and in vivo imaging in mice, demonstrating its use for tracking degenerating neurons and measuring brain oxygen levels.

Neurophotonics · Mar 25, 2025Peer-reviewedNeuroscience

Inference of CRISPR Edits from Sanger Trace Data

Tim Hsiau, David Conant, Nicholas Rossi, Travis J. Maures, Kelsey Waite, Joyce L. Yang, Sahil Joshi, Reed Kelso, Kevin Holden, Brittany L. Enzmann, Rich Stoner

ICE regresses simulated edit traces onto Sanger reads to quantify indels, multi-guide and knock-in edits without tuning, correlating with amplicon sequencing (r2 = 0.93) and TIDE (r2 = 0.99).

bioRxiv · Aug 10, 2019 · PreprintBioinformatics✦ In-depth digest