Nicholas V. Metcalf

Aging and the Spectral Properties of Brain Hemodynamics

The paper examines how aging affects cerebral glucose metabolism by analyzing spectral properties of resting-state fMRI signals and identifies a subset of older adults with divergent patterns linked to white matter pathology.

Precision measurements of brain oxygen utilization with positron emission tomography

This paper develops a model for improving precision in measuring brain oxygen utilization using [15O] tracers and PET, showing that IDIFs provide more reliable results than AIFs.

Generative whole-brain dynamics models from healthy subjects predict functional alterations in stroke at the level of individual patients

The paper uses generative whole-brain models trained on healthy data to predict functional connectivity changes in stroke patients by incorporating lesion-induced structural disconnections.

Brain aerobic glycolysis and resilience in Alzheimer disease

This study finds that preserved aerobic glycolysis in the brain is linked to resilience against Alzheimer's disease pathology, while white matter hyperintensity burden is associated with reduced youthful AG patterns.

Lesion Quantification Toolkit: A MATLAB software tool for estimating grey matter damage and white matter disconnections in patients with focal brain lesions

The paper introduces a MATLAB toolkit for quantifying grey matter damage and white matter disconnections in focal brain lesions, showing consistency with prior literature.

Stroke-related alterations ininter-areal communication

This study investigates how stroke alters long-range brain communication by analyzing functional connectivity and information transfer using resting-state fMRI and Granger causality, revealing inter-hemispheric asymmetries and reduced information transfer.

Spontaneous emergence of behaviorally relevant motifs in human motor cortex

The paper shows that spontaneous activity in human motor cortex resembles common hand movements more than rare ones, suggesting it encodes behaviorally relevant patterns.

Spontaneously emerging cortical representations of visual objects and features in human visual cortex

The paper investigates whether spontaneous brain activity in human visual cortex reflects stimulus-evoked patterns, finding that resting-state patterns are not biased toward specific stimuli but show category-specific fluctuations.

Increases in structural shortest path lengths provide information about the distal neurophysiological consequences of focal brain lesions

This study shows that focal brain lesions disrupt functional connectivity by causing both direct structural disconnections and increases in structural path lengths, leading to remote functional disruptions.

Structural disconnections explain brain network dysfunction after stroke

The paper investigates how structural disconnections, rather than damage to critical regions, explain functional connectivity disruptions and behavioral deficits after stroke.