Foundation cell segmentation models performance on live microscopy and spatial-omics data
Miao Yang, Nick Surguladze, Joshua F. Lerner, Koravit Poysungnoen, Ky Ariano, Yuexi Li, Yining Zhu, Kyra Van Batavia, Jodie Jepson, Josie Van De Klashorst, B. Ni, Alexander Armstrong, Reeha Rahman, Roarke W. Horstmeyer, John W. Hickey
This study evaluates segmentation models on live microscopy and spatial-omics data, finding that no single model consistently outperforms others across all datasets.
bioRxiv · Apr 21, 2026 · PreprintBioinformatics