Roarke W. Horstmeyer

Hydrostatic pressure shapes and canalizes semicircular canal morphology to ensure vestibular function

The paper shows hydrostatic pressure from the inflating otic vesicle shapes zebrafish semicircular canals, driving pillars toward a common geometry and ensuring vestibular function.

Chromatix: a differentiable, GPU-accelerated wave-optics library

Chromatix provides a differentiable, GPU-accelerated wave-optics library to enable fast and parallelized optical simulations for computational optics applications.

Foundation cell segmentation models performance on live microscopy and spatial-omics data

This study evaluates segmentation models on live microscopy and spatial-omics data, finding that no single model consistently outperforms others across all datasets.

Cortex-Wide Cellular Imaging in Freely Locomoting Mice Using Cortex Camera Array Microscope (CortexCAM)

The paper introduces a mobile microscope system, CortexCAM, for imaging large areas of the mouse cortex during natural behaviors.

High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae

This paper introduces a high-throughput 24-camera array microscope for automated 3D behavioral analysis of zebrafish larvae, enabling accurate tracking and morphological dynamics at high frame rates.

Pan-cortical cellular imaging in freely behaving mice using a miniaturized micro-camera array microscope (mini-MCAM)

The paper introduces a miniaturized micro-camera array microscope (mini-MCAM) for wide-field calcium imaging in freely behaving mice, enabling cortex-wide neural activity monitoring.

Parallelized Brightfield and Fluorescence Imaging of Organoids Using a Scalable Multi-Camera Platform

The paper introduces a multi-camera array scanner (MCAS) that significantly reduces imaging time for organoids, enabling faster and more consistent analysis of growth and responses to treatments.

High-speed 4D fluorescence light field tomography of whole freely moving organisms

This paper introduces ReFLeCT, a high-speed volumetric fluorescence imaging technique that captures 4D videos of freely moving zebrafish and Drosophila larvae with high-resolution 3D reconstruction.

SEMPAI: a Self-Enhancing Multi-Photon Artificial Intelligence for prior-informed assessment of muscle function and pathology

SEMPAI integrates hypothesis-driven priors into a deep learning framework to analyze multiphoton microscopy data of muscle fibers, outperforming existing methods in predictive tasks.

Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection

This paper introduces a high-sensitivity DCS system with 1024 parallel detection channels, enabling fast and sensitive measurement of blood flow and physiological variations.