Kyra Van Batavia

This study evaluates segmentation models on live microscopy and spatial-omics data, finding that no single model consistently outperforms others across all datasets.

MINGL quantifies tissue organization by modeling cell memberships across hierarchical units, detecting interfaces, gradients, and heterogeneity in spatial-omic datasets.

The paper examines TIL expansion in glioblastoma by analyzing spatial organization and myeloid context, finding that TIL+ tumors have distinct immune interactions and vascular niches.

The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.