Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose
Melissa Lever, Hong-Sheng Lim, Philipp Kruger, John Nguyen, Nicola Trendel, Enas Abu-Shah, Philip K Maini, Philip Anton van der Merwe, Omer Dushek
The paper identifies a minimal signaling model that explains T cell responses across a wide range of antigen affinity and dose variations.
bioRxiv · Aug 27, 2016Immunology