Philip K Maini

Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose

The paper identifies a minimal signaling model that explains T cell responses across a wide range of antigen affinity and dose variations.

Spatial metrics of tumour vascular organisation predict radiation efficacy in a computational model

This paper uses a computational model to show that spatial organization of blood vessels in tumors affects radiation response, with varying correlations depending on vessel density.

Exploiting evolutionary non-commutativity to prevent the emergence of bacterial antibiotic resistance

This paper develops a Markov Chain model to analyze antibiotic resistance emergence in E. coli and shows that drug sequencing can probabilistically steer populations away from resistance.

A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy

This paper proposes a physical network model of CTC flow to predict metastatic patterns and improve staging of oligometastatic disease.

Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy

This paper develops a spatial mathematical model of glucose-lactate metabolism in tumors and finds that metabolic symbiosis is robust and may enhance oxygenation, suggesting potential for targeted therapy.