Understanding the role of chromatin accessibility and compaction on loop extrusion dynamics
Nicolas Pellet, Cesar Lopez Pastrana, Axel Delamarre, Dario D’Asaro, Pascal Bernard, Daniel Jost
This paper develops a biophysical model of loop extrusion that links motor dynamics to chromatin accessibility and compaction, revealing how nucleosome spacing affects extrusion speed.
bioRxiv · Oct 14, 2026 · PreprintBiophysics