Pascal Bernard

This paper develops a biophysical model of loop extrusion that links motor dynamics to chromatin accessibility and compaction, revealing how nucleosome spacing affects extrusion speed.

The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

The paper shows that RNA Pol II inhibits condensin's ability to fold mitotic chromatin and support chromosome segregation in fission yeast.

This study shows that SenataxinSen1 promotes RNA Polymerase III transcription termination in fission yeast independently of R-loops.

This study shows that the sequence of the non-template strand determines the three-dimensional architecture of R-loops, which influences their impact on genome stability.

This study shows condensin affects RNA levels by causing chromosome missegregation, not by directly regulating transcription.

This study shows that dsRNAs interfere with R-loop detection using S9.6 antibody-based DRIPc-seq in fission yeast, revealing genuine R-loops and their transcriptomic impact.