Challenging the Astral mass analyzer - up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity.
Julia A. Bubis, Tabiwang N. Arrey, Eugen Damoc, Bernard Delanghe, Jana Slovakova, Theresa M. Sommer, Harunobu Kagawa, Peter Pichler, Nicolas Rivron, Karl Mechtler, Manuel Matzinger
This paper introduces a high-throughput single-cell proteomics workflow achieving 5300 protein groups per cell with high accuracy, enabling the study of cellular heterogeneity and lineage differentiation.
bioRxiv · Feb 1, 2024 · PreprintBiochemistry