Transposable elements as evolutionary substrates of proteindisorder in the human proteome
Juan Mac Donagh, Nicolas Vergesio, Andrea Aguilar, Rodrigo Nores, Antonio Lagares, Marı́a Silvina Fornasari, Gustavo D. Parisi
The paper identifies transposable elements as a source of intrinsic disorder in human proteins, showing that TE insertions are enriched in disordered regions and their conformational fate depends on their age and TE class.
bioRxiv · Jun 14, 2026 · PreprintBioinformatics