Juan Mac Donagh

The paper identifies transposable elements as a source of intrinsic disorder in human proteins, showing that TE insertions are enriched in disordered regions and their conformational fate depends on their age and TE class.

The paper uses AlphaFold2 to predict protein-ligand interactions in disordered regions, identifying 'ghost interactions' not captured in crystal structures.

This study evaluates AlphaFold2's ability to predict ensemble protein conformations and finds it struggles with conformational diversity, with performance worsening as diversity increases.