Exercise remodels hippocampal extracellular matrix to alleviate chondroitin-4-sulphate-induced memory impairment.
Natalie E. Doody, Ben Stevens, Nicole J. Smith, Varinder K. Lall, Sally Boxall, Ruth Hughes, Elizabeth C. Akam, Graham N. Askew, Jessica C. F. Kwok, Ronaldo M. Ichiyama
This study shows that exercise reduces aggrecan expression and alters perineuronal nets in the hippocampus, improving memory by modulating inhibitory pathways.
bioRxiv · Nov 14, 2025 · PreprintNeuroscience