Jessica C. F. Kwok

4-Methylumbelliferone Restores Age-Related Changes in Perineuronal Nets, Memory and Neuroinflammation

This study shows that 4-MU reduces PNNs, improves memory, and decreases neuroinflammation in aged mice.

Intertwined Autophagy and Integrin Dynamics Shape Axon Growth and Regeneration

This study investigates the relationship between autophagy and integrin dynamics in axon growth and regeneration, finding a bidirectional feedback system that regulates these processes.

Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in aging

This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.

Long-Term Expression and Safety of AAV1-Mediated PI3Kδ Overexpression in the Adult Rat Cortex

This study shows that long-term PI3Kδ overexpression in adult rat cortex using AAV1 is safe and well-tolerated, with no adverse effects observed over one year.

Exercise remodels hippocampal extracellular matrix to alleviate chondroitin-4-sulphate-induced memory impairment.

This study shows that exercise reduces aggrecan expression and alters perineuronal nets in the hippocampus, improving memory by modulating inhibitory pathways.

Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract

This study shows that increasing PI3K{delta} activity in adult rat cortical neurons promotes corticospinal tract regeneration and functional recovery after spinal cord injury.

Recovery of forearm and fine digit function after chronic spinal cord injury by simultaneous blockade of inhibitory matrix CSPG production and the receptor PTPσ.

This study shows that blocking CSPG production and the receptor PTPσ improves functional recovery in chronic spinal cord injury models.

Alpha 9 integrin expression enables reconstruction of the spinal cord sensory pathway.

This paper demonstrates that expressing alpha 9 integrin and its activator kindlin-1 in sensory neurons enables axon regeneration through spinal cord injuries in rats, restoring sensory function.

Oral administration of 4-methylumbelliferone reduces glial scar and promotes anatomical plasticity

This study evaluates the effect of 4-MU on spinal cord injury in rats, showing reduced HA synthesis and glial scar but insufficient functional recovery.

4-methylumbelliferone enhances neuroplasticity in the central nervous system: potential oral treatment for SCI

This study shows that 4-MU removes perineuronal nets and enhances plasticity in the central nervous system, offering a potential oral treatment for spinal cord injury.

Perineuronal nets affect memory and learning after synapse withdrawal

This study examines the role of perineuronal nets (PNNs) in memory and learning after synaptic withdrawal induced by an hibernation-like state, finding that PNN absence affects synaptic restoration but not long-term memory storage.

An in vitro neuronal model replicating the in vivo maturation and heterogeneity of perineuronal nets

This paper develops a primary neuronal culture model that replicates the in vivo maturation and heterogeneity of perineuronal nets.

Immunochemical analysis of the integrin expression in retinal pigment epithelial cells

The paper analyzes integrin expression in primary rat RPE cells and the human ARPE-19 cell line using immunochemistry, finding that both express integrins, with ARPE-19 increasing expression after long-term culturing.