A bi-directional binding site linking the α2δ-1 subunit to the intrinsic speed control process in VSD I of voltage-gated calcium channels
Martin C. Heiss, Monica L. Fernández‐Quintero, Nicole Kranbitter, Hajar El Aouad, Marta Campiglio, Bernhard E. Flucher
This study identifies a bi-directional binding site between the α2δ-1 subunit and the voltage-sensing domain I of calcium channels, revealing how it modulates activation kinetics.
bioRxiv · Oct 7, 2025 · PreprintBiophysics