Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling
Neuza S. Domingues, Alessia Calcagnì, Sofia Roque Freire, Joana Pires, Ricardo Casqueiro, Ivan L. Salazar, Niculin J. Herz, Tuong Huynh, Katarzyna Wieciorek, Tiago F. Outeiro, Henrique Girão, Ira Milošević, Andrea Ballabio, Nuno Raimundo
This study shows that loss of CLN3 disrupts lysosomal lipid metabolism, leading to nuclear envelope lipid changes, DNA damage, and YAP1-driven apoptosis in Batten disease models.
EMBO Reports · Nov 6, 2025Peer-reviewedCell Biology