Structure-Based Drug Design of Novel Inhibitors Targeting the Thiamine Biosynthesis Pathway in Bacteria
Nikil Krishna, Venkatasubramanian Ulaganathan
The paper designs novel inhibitors targeting thiamine biosynthesis in bacteria using structure-based drug design, resulting in a potent orally bioavailable broad-spectrum bactericidal molecule.
bioRxiv · Oct 12, 2026 · PreprintBioinformatics