Reference-free deconvolution of complex DNA methylation data - a systematic protocol
Michael Scherer, Petr V. Nazarov, Réka Tóth, Shashwat Sahay, Tony Kaoma, Valentin J. Maurer, Nikita Vedeneev, Christoph Plass, Thomas Lengauer, Jörn Walter, Pavlo Lutsik
This paper introduces a reference-free deconvolution protocol for DNA methylomes to identify hidden cell populations in complex samples, applied to lung cancer data from TCGA.
Nature Protocols · Sep 25, 2020Peer-reviewedBioinformatics