Tony Kaoma

The paper identifies impaired monocyte states and trajectories in glioblastoma patients through immune profiling, revealing systemic immune reprogramming and potential therapeutic targets.

This study shows that Daunorubicin induces transcriptional changes in AML cells through SUMO-dependent chromatin reconfiguration, affecting genes related to proliferation, death, and immunity.

This study uses a synuclein-transgenic mouse model to identify molecular changes in early Parkinson's disease before neurodegeneration occurs.

This paper introduces a reference-free deconvolution protocol for DNA methylomes to identify hidden cell populations in complex samples, applied to lung cancer data from TCGA.

The paper investigates the role of alpha-synuclein spreading and inclusions in Parkinson disease using a mouse model, finding that neurodegeneration and microgliosis occur independently of inclusions.

The paper introduces a drug sensitivity prediction system using a 47-gene expression profile derived from transcriptomic analysis, validated with independent datasets and showing high concordance with observed drug responses.