Valentin J. Maurer

scIRES-seq reveals multimodal molecular heterogeneity in CTCs from small cell cervical cancer

This study introduces scIRES-seq to analyze CTCs from cervical cancer, revealing multimodal molecular heterogeneity through integrated genetic, epigenomic, and transcriptomic profiling.

Constrained template matching using rejection sampling

This paper introduces rejection sampling to improve macromolecular complex detection in cryo-electron tomography by incorporating biological constraints, achieving performance comparable to deep learning methods without annotated data.

Physics-based, data-driven cell-scale membrane simulations with HMFF

The paper introduces HMFF, a method integrating experimental data into membrane simulations, and applies it to various biological systems to enable multi-scale modeling.

AlphaPulldown2 - A General Pipeline for High-Throughput Structural Modeling

AlphaPulldown2 provides a pipeline for high-throughput protein structural modeling with automated workflows and improved data management.

ColabSeg: An interactive tool for editing, processing, and visualizing membrane segmentations from cryo-ET data

ColabSeg is a tool for processing and visualizing membrane segmentations from cryo-ET data, enabling high-throughput segmentation and training of CNNs.

PyTME (Python Template Matching Engine): A fast, flexible, and multi-purpose template matching library for cryogenic electron microscopy data

The paper introduces pyTME, a Python library for template matching in cryo-EM data that improves efficiency and scalability for large datasets.

Reference-free deconvolution of complex DNA methylation data - a systematic protocol

This paper introduces a reference-free deconvolution protocol for DNA methylomes to identify hidden cell populations in complex samples, applied to lung cancer data from TCGA.