BAP1 loss impairs Non-Homologous End Joining DNA repair promoting genomic instability
Sabrina Caporali, Carla Schuy, Alessio Butera, Melanie Rall-Scharpf, Nils Geese, Lisa Wiesmüller, Ivano Amelio
This study shows BAP1 loss impairs NHEJ DNA repair by promoting H2AK119-ub accumulation and excessive end resection, leading to genomic instability in uveal melanoma.
bioRxiv · Apr 27, 2026 · PreprintCancer Biology