Human and Rodent Seizures Demonstrate a Dynamic Interplay with Spreading Depolarizations
Jacob H Norby, Daniel Hummel, Noah Ricks, John David Rolston, Shervin Rahimpour, Rhiannon L Cowan, Juha Voipio, Andrew J. Trevelyan, Elliot H. Smith, R. Ryley Parrish
This study shows that spreading depolarizations (SDs) are associated with seizure termination in both human and rodent models, with SDs reducing seizure duration and delaying subsequent events.
Neurobiology of Disease · May 8, 2025Peer-reviewedNeuroscience