Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimers disease
Maria Elizabeth de Sousa Rodrigues, MacKenzie L. Bolen, Lisa Blackmer‐Raynolds, Noah Schwartz, Jianjun Chang, Malú G. Tansey, Timothy Robert Sampson
The paper shows that a high-fat, high-carbohydrate diet causes sex-specific metabolic and inflammatory issues in 5xFAD mice, which are partially reversed by inhibiting soluble TNF in males.
Neurobiology of Disease · Apr 24, 2024Peer-reviewedNeuroscience