Jianjun Chang

This study shows human astrocytes can present antigens via MHCII after chronic cytokine exposure, revealing their potential as antigen-presenting cells.

This study shows that gut microbes influence the transcriptional states of brain cell types and affect neurodegenerative disease susceptibility, with E. coli specifically worsening Alzheimer's disease outcomes in mice.

This study shows the gut microbiome is necessary for host detoxification responses to deltamethrin, with both developmental and active microbial signaling contributing to hepatic and colonic detoxification.

This study shows deltamethrin disrupts monoamine and neuropeptide signaling in EECs, leading to reduced intestinal motility and hormone release.

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

This study shows that dietary fiber and microbiome-derived metabolites protect the enteric nervous system after spinal cord injury by modulating immune signaling.

The paper assesses cognitive and motor function in APPSAA and APPWT mice over 12 months, finding no age-related cognitive decline but increased fecal output in APPSAA mice.

The paper shows that a high-fat, high-carbohydrate diet causes sex-specific metabolic and inflammatory issues in 5xFAD mice, which are partially reversed by inhibiting soluble TNF in males.

This study develops a transgenic mouse model expressing human alpha-synuclein in noradrenergic neurons, revealing LC pathology and non-motor PD features.