Downregulations of mRNA expressions in the EPAS1and EGLN1: Unraveling a genetic mechanism for high-altitude hypoxia adaptation in Sherpa highlanders
Yunden Droma, Fengming Yue, Masao Ôta, Nobumitsu Kobayashi, Yoshiaki Kitaguchi, Masayuki Hanaoka
This study investigates mRNA expression levels of EPAS1 and EGLN1 in Sherpa highlanders and lowlanders, finding lower expressions in Sherpa highlanders and associations with specific SNPs that may contribute to hypoxia tolerance.
bioRxiv · May 23, 2024 · PreprintGenetics