Physiological load via voluntary wheel running maintains Achilles tendon homeostasis by region-specific cellular responses
Samantha N. Muscat, Elsa Lecaj, Nolan Sparks, Alexander Kollar, Eowyn Kroening, Mark R. Buckley, Anne E. C. Nichols
This study shows that voluntary wheel running induces region-specific cellular responses in mouse Achilles tendon that maintain homeostasis by altering collagen fibril size and gene expression.
bioRxiv · May 29, 2026 · PreprintCell Biology