Retrospective Computational and Immunoinformatics Validation of Clinically Evaluated Necator americanus Protein Vaccine Candidates: Na-APR-1, Na-GST-1, and Na-ASP-2
Yanick Aqua Stong Tangan, Gordon Takop Nchanji, Marcel Nyuylam Moyeh, Teke Mary Efeti, Lahngong Methodius Shinyuy, Pilate Nkineh Kwi, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Che Roland Achungu, Cabirou Mounchili Shintouo, Melvis Berinyuy Dulandzev, Ntang Emmaculate Yaah, Bernis Neneyoh Yengo, Beltine Muyer Tamnjong, Ketura Yaje Gwei, , Robert Adamu Shey
This paper retrospectively evaluates the safety and immunogenicity of three hookworm vaccine candidates using immunoinformatics, identifying Na-APR-1 as the most promising with broad epitope coverage and favorable TLR4 interactions.
bioRxiv · Sep 8, 2026 · PreprintImmunology