Fluid Shear Stress-Induced Changes in Megalin Trafficking Enhance Endocytic Capacity in Proximal Tubule Cells
E. M. Lackner, I. A. Cowan, K. R. Long, O. A. Weisz, K. E. Shipman
This study shows that fluid shear stress increases megalin trafficking rates in proximal tubule cells, enhancing endocytic capacity and drug uptake, despite reduced surface megalin levels.
bioRxiv · Feb 22, 2024Physiology