O. Campas

In situ quantification of osmotic pressure within living embryonic tissues

The paper introduces a method to measure osmotic pressure in living tissues and finds a balance between intracellular and interstitial pressures in zebrafish embryos.

A nuclear jamming transition in vertebrate organogenesis

The paper identifies a nuclear jamming transition during vertebrate organogenesis, showing that nuclear packing influences tissue mechanics and architecture beyond cellular jamming.

Optimal mechanical noise ensures robust vertebrate body segmentation

This study shows that optimal mechanical noise and boundary tension in zebrafish embryos ensure robust somite formation and body segmentation.

STRESS, an automated geometrical characterization of deformable particles for in vivo measurements of cell and tissue mechanical stresses

The paper introduces STRESS, an automated software to quantify mechanical stresses from microdroplet deformations in 3D multicellular systems, demonstrating its application in zebrafish embryos.

Coordinating cell polarization and morphogenesis through mechanical feedback

This study shows that mechanical feedback from the Cell Wall Integrity Pathway helps maintain cell polarization during morphogenesis in budding yeast.

Mechanics of the cellular microenvironment as perceived by cells in vivo

The paper quantifies in vivo mechanical parameters perceived by cells during vertebrate presomitic mesoderm specification, showing cells probe supracellular stiffness and experience time-dependent stress relaxation.

Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation

This study theoretically examines how fluid-to-solid tissue transitions control morphogenetic flows and shape during vertebrate body axis elongation, showing that tissue surface tension and fluid-solid transitions determine unidirectional elongation.

Embryonic Tissues as Active Foams

This study develops a computational framework to describe embryonic tissue dynamics, revealing a tension-fluctuation-driven rigidity transition.

Physical constraints on early blastomere packings

This study simulates early embryonic cell packings to show that physical confinement determines 4-cell stage arrangements, overriding division rules and ensuring robust configurations.