The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice
O. H. Wearing, C. M. Ivy, N. Guttierrez-Pinto, J. P. Velotta, S. C. Campbell-Staton, C. Natarajan, Z. A. Cheviron, J. F. Storz, G. R. Scott
This study shows that increased hemoglobin-O2 affinity in high-altitude deer mice only benefits aerobic thermogenesis if paired with improved tissue O2 diffusion capacity.
bioRxiv · Oct 29, 2020Physiology