C. Natarajan

Efficiently determining membrane-bound conformations of peripheral membrane proteins using replica exchange with hybrid tempering

This study demonstrates that the REHT method efficiently samples membrane-bound conformations of the Osh4 ALPS peptide, revealing a preference for horizontal over vertical conformations.

Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin

This study investigates the molecular basis of a novel allosteric property in crocodilian hemoglobin by resurrecting ancestral proteins and performing directed mutagenesis.

New insights into the allosteric effects of CO2 and bicarbonate on crocodilian hemoglobin

This study provides the first experimental evidence that bicarbonate binds directly to crocodilian hemoglobin, promoting O2 delivery independently of CO2.

Genetic variation in haemoglobin regulates breathing in high-altitude deer mice

This study shows that genetic variation in haemoglobin affects breathing patterns in high-altitude deer mice, independent of its role in oxygen transport.

The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

This study shows that increased hemoglobin-O2 affinity in high-altitude deer mice only benefits aerobic thermogenesis if paired with improved tissue O2 diffusion capacity.

Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (Boleophthalmus pectinirostris)

This study examines hemoglobin oxygenation properties and genomic origins of isoform multiplicity in the blue-spotted mudskipper, finding similar oxygen transport traits to hypoxia-tolerant fish despite functional isoform diversity.

The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function

The paper examines how mutation bias at CpG dinucleotides influences adaptive molecular evolution by analyzing convergent changes in hemoglobin function across high-altitude birds.