Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis
V. M. Bii, D. Rudoy, O. Klezovitch, V. Vasioukhin
This study shows that Llgl1 and Llgl2 function as tumor suppressors in mouse skin epidermis by promoting squamous cell carcinoma development when combined with Trp53 loss.
bioRxiv · Mar 6, 2023 · PreprintCancer Biology