Comparison of mitochondrial response to SARS-CoV-2 spike protein receptor binding domain in human lung microvascular, coronary artery endothelial and bronchial epithelial cells
G. Kulkoviene, D. Narauskaite, A. Tunaityte, A. Volkeviciute, Z. Balion, O. Kutakh, D. Gecys, M. Kairyte, M. Uldukyte, E. Stankevicius, A. Jekabsone
The paper examines how SARS-CoV-2 spike protein RBD affects mitochondrial function and inflammation in three human cell types, finding increased mitoROS and cytokine expression in all, with HLMVEC showing the strongest response.
bioRxiv · Dec 19, 2023 · PreprintImmunology