Genomic Retargeting of Tumor Suppressors p53 and CTCF Promotes Oncogenesis
M. Schwartz, A. Sarusi Portugez, B. Zukerman Attia, M. Tannenbaum, O. Loza, A. Chase, Y. Turman, T. Kaplan, Z. Salah, O. Hakim
The paper identifies p53 and CTCF as key regulators of transcriptional reprogramming in early oncogenic transformation driven by HRas, showing that chromatin redistribution, not expression changes, drives malignancy.
bioRxiv · Jul 23, 2019 · PreprintCell Biology