Cell BiologybioRxivPreprint
p16High senescence restricts totipotent potential during somatic cell reprogramming
B. B. Grigorash, D. van Essen, L. Grosse…·D. Bulavin
This study shows that removing p16High senescent cells enhances 4F-induced reprogramming of somatic cells into totipotent-like stem cells by modulating NNMT and SAM levels.
DOI 10.1101/2022.08.24.504108