Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic
J. Cholewa-Waclaw, R. Shah, S. Webb, K. Chhatbar, B. Ramsahoye, O. Pusch, M. Yu, P. Greulich, B. Waclaw, A. Bird
The paper uses mathematical modeling and experimental analysis to show MeCP2 creates 'slow sites' in gene bodies, affecting RNA polymerase II traffic and gene expression.
bioRxiv · Feb 28, 2019Biophysics