B. Waclaw

Infection dynamics in the urinary tract - The importance of non-planktonic phases during early infection and resistance evolution

This study uses a mathematical model to show that non-planktonic bacterial phases in UTIs increase infection risk and shape resistance evolution, with probiotic pretreatment improving antibiotic efficacy.

Substrate geometry affects population dynamics in a bacterial biofilm

This study shows that surface geometry influences genetic drift and selection in bacterial biofilms, with undulating surfaces creating stable clonal sectors that resist mixing and expansion.

Rapid Evolution of Colistin Resistance in a Bioreactor Model of Infection of Klebsiella pneumoniae

This study shows that colistin resistance in K. pneumoniae evolves rapidly through spontaneous mutations in regulatory genes during treatment.

Predictable Properties of Fitness Landscapes Induced by Adaptational Tradeoffs

The paper develops a mathematical model of fitness landscapes shaped by adaptational tradeoffs, showing predictable properties and accessible evolutionary paths despite ruggedness.

Phenotypic delay in the evolution of bacterial antibiotic resistance: mechanistic models and their implications

The paper investigates phenotypic delay in bacterial antibiotic resistance evolution using simulations and theory, showing that dilution of sensitive molecules and effective polyploidy cause delay, affecting survival and mutation rate estimates.

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic

The paper uses mathematical modeling and experimental analysis to show MeCP2 creates 'slow sites' in gene bodies, affecting RNA polymerase II traffic and gene expression.

On measuring selection in cancer from subclonal mutation frequencies

The paper develops a stochastic model to analyze subclonal mutation frequencies in cancer, showing that driver mutations are biased towards extreme frequencies and that the 1/f power law may overestimate neutral evolution.

Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations

The paper models mechanical interactions in bacterial colonies and shows how physical properties affect the surfing probability of beneficial mutations.

An exactly solvable, spatial model of mutation accumulation in cancer

This paper presents an exactly solvable mathematical model of tumour growth and mutation accumulation, showing exponential mutation increase under constant fitness gains and a plateau under decreasing gains.