R. Shah

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

In Vitro Efficacy of Next Generation Dihydrotriazines and Biguanides Against Babesiosis and Malaria Parasites

This study screens dihydrotriazines and biguanides against Babesia and Plasmodium parasites to identify effective antifolates with broad-spectrum activity and high therapeutic indices.

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

Historic breeding practices contribute to germplasm divergence in leaf specialized metabolism and ecophysiology in cultivated sunflower (Helianthus annuus).

This study examines how historical breeding practices in sunflower affect leaf ecophysiology and specialized metabolism by analyzing 288 cultivated lines across heterotic groups.

Lipidomics of homeoviscous adaptation to low temperatures in Staphylococcus aureus utilizing exogenous straight-chain unsaturated fatty acids over biosynthesized endogenous branched-chain fatty acids

This paper shows that Staphylococcus aureus uses exogenous unsaturated fatty acids to enhance growth at low temperatures through lipid remodeling and carotenoid production.

Characterization and optimization of variability in a human colonic epithelium culture model

The paper characterizes and reduces variability in a human colonic epithelium culture model to improve its predictive value for drug responses.

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION

This study shows that CB2R on microglia drives neuroinflammation in GVHD by promoting T cell activation and neuronal death, and that targeting CB2R reduces inflammation without worsening systemic GVHD.

PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosis

The paper identifies PAK1-dependent mechanotransduction as critical for myofibroblast nuclear adaptation and chromatin organization during fibrosis, showing its impact on gene regulation and disease progression.

Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

The paper shows that airway epithelial cells efficiently kill inhaled Aspergillus fumigatus spores in vivo, but this process is impaired in COPD.

Subgenomic SARS-CoV-2 replicon and reporter replicon cell lines enable ultrahigh throughput antiviral screening and mechanistic studies with antivirals, viral mutations or host factors that affect COVID-19 replication

This paper develops SARS-CoV-2 replicon systems and cell lines for antiviral screening and mechanistic studies, enabling research at lower biosafety levels.

The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix

The paper uses spatial proteomics to show that the IPF fibroblastic focus is a major site of collagen biosynthesis with distinct ECM composition compared to surrounding tissues.

Redox-mediated inactivation of the transcriptional repressor C3600 makes uropathogenic Escherichia coli exquisitely resistant to reactive chlorine species

This study identifies a redox-mediated mechanism in UPEC that enhances resistance to HOCl by inactivating the transcriptional repressor C3600 through disulfide bond formation.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

Inclusion of a 3D-printed Hyperelastic bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold

This study shows that adding a 3D-printed Hyperelastic Bone mesh to a mineralized collagen scaffold improves mechanical strength and osteogenic performance in bone regeneration.

Disparities in information on Long-Acting Reversible Contraceptives available to college students on student health center websites in USA

The paper examines disparities in LARC contraceptive information availability on college student health center websites in the USA, finding limited coverage and organizational inconsistencies.

Anti-tumor effects of an Id antagonist with no acquired resistance

This study demonstrates that AGX51, an Id antagonist, effectively inhibits tumor growth in multiple cancer models without inducing acquired resistance.

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

The complex genetic architecture of recombination and structural variation in wheat uncovered using a large 8-founder MAGIC population

The paper develops a large MAGIC population in wheat to uncover genetic architecture of recombination and structural variation, identifying significant QTLs and epistatic interactions.

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic

The paper uses mathematical modeling and experimental analysis to show MeCP2 creates 'slow sites' in gene bodies, affecting RNA polymerase II traffic and gene expression.

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

This study shows ATRX deficiency in glioma causes genomic instability via G-quadruplex DNA, and G4 stabilization can be therapeutically targeted.

Signaling architectures that transmit unidirectional information despite retroactivity

This study identifies signaling architectures that enable unidirectional information transmission by overcoming retroactivity, showing that cascades of single-stage systems can achieve this while others cannot.