A rule-based multiscale model of hepatic stellate cell plasticity: critical role of the inactivation loop in fibrosis progression
Matthieu Bouguéon, Vincent Legagneux, Octave Hazard, Jérémy Bomo, Anne Siegel, Jérôme Ferêt, Nathalie Théret
This paper develops a rule-based model of hepatic stellate cell dynamics in fibrosis, showing the critical role of inactivation loops in fibrosis progression and identifying inactivated HSCs as markers of fibrosis.
PLoS Computational Biology · Jul 29, 2024Peer-reviewedSystems Biology