Mechanism underlying PilC/PilY1 role in type 4a pilus biogenesis at a late stage occurring after filament assembly
Milica Denic, Morgane Wuckelt, V. Roig-Zamboni, Odile Valette, Nicolas Biais, Latifa Elantak, Gerlind Sulzenbacher, Mathieu Coureuil, Vladimir Pelicic
The paper identifies the role of the PilC/PilY1 plug region in T4a pilus biogenesis, showing it interacts with PilK to stabilize the protein and enable pilus formation after filament assembly.
bioRxiv · Oct 18, 2026 · PreprintMicrobiology