Dual Immune Checkpoint and Cytokine Receptor Modulation by an Engineered Human CTLA-4/IL-10 Bispecific Fusion Protein
Adi Cohen, Matan Gabay, Omri Cohen, Marina Sova, Amihai Lieberman, Anat Shemer, Nira Varda‐Bloom, Elad Jacoby, Gal Cafri, Dorit Avni, Itamar Yadid, Maayan Gal
This paper describes the engineering of a bispecific fusion protein combining CTLA-4 and IL-10 to modulate immune checkpoints and cytokine receptors, showing T cell-inhibitory effects in vitro.
bioRxiv · May 12, 2026 · PreprintBioengineering